NP137 prevents the binding of Netrin-1 to UNC5B Receptor, hereby, re-inducing cancer cell death.
Based on:
- Forcet et al. 2001, PNAS 104, 1212-22
- Tang et al. 2008, Nat Cell Biol., 10, 698-706
- Mille et al., 2009, Nat Cell Biol., 24, 1192-01
- Fombonne et al., 2012, PNAS, 109, 10510
Anti-cancer effects both as standalone and in combination with chemotherapy or immune checkpoints have been demonstrated during preclinical experiments.