RadioLigand Therapy

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Anti-netrin1 RadioLigand Therapy

Radioligand Therapy consists in the use of radioisotopes coupled to targeting moieties such as peptide or antibodies to achieve a localized delivery of radiotherapy for diagnostic and therapeutic purposes.

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The confined expression of netrin-1 in the tumor microenvironment sparked interest in developing a novel radio-conjugate approach, coupling anti-netrin1 compounds with selected radioisotopes, to more selectively target tumor cells. Pharmacological models confirm the potential of this innovative method for both imaging and therapeutic purposes.

This project is conducted in collaboration with INSERM and Orano.

Capture d’écran 2024-09-30 à 11.14.32
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