Reading : 2 minutes

NETRIS Pharma is pleased to announce that the ANR (Agence Nationale de la Recherche) allocated a 6.6 M€ grant to the RHU DEPGYN project aiming to develop new therapeutic approaches targeting the dependence receptors in gynecological cancers.

This project will be coordinated by Prof. Jean-Yves Blay, Director of the Léon Bérard comprehensive cancer center, and will consist in collaboration with NETRIS Pharma and Deeplink Medical (i) in performing a clinical POC exploring the netrin-1 mAb in combination with anti-cancer drugs and ICPI in gynecological cancers, renowned for their poor prognosis in advanced stages and for the lack of efficient systemic therapies. Additional aims include (ii) improving general knowledge on DRs in the biology of human cancers in vivoand the associated MoA of interfering with netrin-1/DR interactions, as well as (iii) to perform an ambitious ancillary/translational program to identify biomarkers of efficacy for each netrin-1 mAb/combination treatment.

For further details, see:



Suggested articles

logo Nature article

NETRIS Pharma announces data published in two Nature papers confirming netrin-1 blockade as significant clinical strategy in oncology

* Anti-netrin-1 monoclonal antibody, NP137, demonstrates objective response and disease stabilization as monotherapy in Phase 1 study of patients with advanced endometrial carcinoma (EC); effective in inhibiting tumor growth in several different preclinical mouse models. * Paired biopsies, pre-and-on NP137 treatment, highlight a statistically significant reduction of tumor epithelial-to-mesenchymal transition. * Netrin-1 blockade with NP137, is confirmed as a clinical strategy to alleviate resistance to standard treatments, in multiple clinical indications, including EC.

Reading : 15 min
Bio Boston 2023

NETRIS Pharma attending the Bio International Convention in Boston (June 5-8, 2023)

NETRIS Pharma, a clinical-stage immuno-oncology pharmaceutical company pioneering NETRIN-1-based drug discovery and development, is confirming today that CEO and Founder Patrick Mehlen, and CFO Christophe Guichard, will be attending the Bio International Convention taking place June 5-8, 2023, in Boston, MS. Meet with us at the Partnering booth ! For any information, please send an email to christopheguichard@netrispharma.com

Reading : 1 min

NETRIS Pharma Doses First Patient in Pancreatic Cancer Clinical Study with NP137

Lap-NET1 study will evaluate safety and efficacy of anti-netrin-1 antibody NP137 in combination with m_FOLFIRINOX for first line patients with Locally Advanced Pancreatic Ductal Adenocarcinoma

Reading : 5 min